A Genetic Susceptibility Mechanism for Major Depression

A Genetic Susceptibility Mechanism for Major Depression

Major Depression (MD) is a highly inherited psychiatric disorder. The norepinephrine transporter (NET) gene plays important role in pathophysiology of MD. This study attempted to examine the relationship between polymorphisms of NET gene and MD. Patients with MD and healthy controls were recruited and subgrouped. The T-182C and G1287A polymorphisms of NET gene were genotyped by direct sequencin...

5-HTTLPR Polymorphism impacts cingulate-amygdala interactions: A genetic susceptibility mechanism for depression

A breakthrough treatment for major depression.

I this issue, Özdemir and colleagues1 have shown that treatment of severe major depression can now be greatly improved by safe, simple, and readily available bright light treatment. Patients may benefit within a week. Moreover, the benefit persisted throughout 8 weeks of observation even after the bright light treatment was discontinued. What seemed unique in this new study is the focus on hosp...

Genetic epidemiology of major depression: review and meta-analysis.

OBJECTIVE The authors conducted a meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression. METHOD The authors searched MEDLINE and the reference lists of previous review articles to identify relevant primary studies. On the basis of a review of family, adoption, and twin studies that met specific inclusion criteria, the authors derived quantitative ...

Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q.

The epilepsies are a group of disorders characterised by recurrent seizures caused by episodes of abnormal neuronal hyperexcitability involving the brain. Up to 60 million people are affected worldwide and genetic factors may contribute to the aetiology in up to 40% of patients. The most common human genetic epilepsies display a complex pattern of inheritance. These are categorised as idiopathi...